Immunohistochemistry

Our Immunohistochemistry section provides a composite panel of immunohistochemical antibodies in use as diagnostic, prognostic and predictive markers in oncologic diagnosis. In addition IHC markers for specific infections can also be performed.

Organ/tumor/infection specific markers are listed below:

Breast

ER, PR, HER-2, Ki67, e-cadherin, p63, CK14, CK5/6, GCDFP-15, calponin, caldesmon

Lung/pleura

TTF-1, p63, CK7, CK 20, BerEp4, napsin A, EMA, calretinin, WT-1

Gastrointestinal tract/liver

CK7, CK20, CDX2, CEA, CD117, DOG-1, CA 19.9, neuroendocrine markers (listed below), glypican3, Hep Par1, Hepatocyte

Thyroid

CK19, HBME-1, HMWCK

Ovary, uterus and cervix; germ cells

CA125, WT-1, p53, CEA, p16, vimentin, PR, ARID1A, inhibin, CD117, AFP

Haematolymphoid

CD2, CD3, CD4, CD5, CD7, CD 8, CD10, CD19, CD15, CD20, CD21, CD23, CD30, CD43, CD 44, CD45 (LCA), CD45RO, CD56, CD57, CD79a, CD61, CD68, CD117, CD1a, cyclinD1, MUM-1, , PAX5, OCT2, BOB1, Tdt, bcl2, bcl6, Alk-1, CD138, (kappa, lambda, EBV by ISH), fascin, MPO, Glycophorin A and C

Renal/bladder/Prostate

PSA, PAP, 34betaE12, AMACR, PAX2, RCC

Neural/Neuroendocrine

GFAP, NFP, NSE, S-100, INI1, IDH1, Synaptophysin, chromogranin A, CD56, calcitonin

Soft tissue and bone

Vimentin, Smooth muscle actin(SMA), desmin, beta catenin, CD31, CD34, D2-40, Factor VIII, Factor XIIIa, MyoD-1, myogenin

Cancer of unknown primary (includes germ cell and melanoma markers)

CK AE1/3, CK CAM 5.2, CK7, CK20, ER, WT-1, PAX-8, GCDFP15, PSA, cdx2, CK17, CK19, uroplakin, melan A, HMB45, AFP

Specific infections

CMV, HPV, HSV, HHV8, EBV